abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

journal_title：Journal of bone and mineral metabolism

authors： Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

更新日期：2011-03-01 00:00:00

abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

journal_title：Journal of bone and mineral metabolism

authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2011-03-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：:There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral ne...

journal_title：Journal of bone and mineral metabolism

authors： Wu SY,Qi J,Lu Y,Lan J,Yu JC,Wen LQ,Zhang ZL

更新日期：2010-11-01 00:00:00

abstract：:Various animal experiments and human studies have shown that intermittent injections of parathyroid hormone (PTH) exert anabolic effects on bone, whereas continuous PTH treatment decreases the bone mass and causes hypercalcemia in animals. However, limited data are available with regard to the effects of a repetitive ...

journal_title：Journal of bone and mineral metabolism

authors： Etoh M,Yamaguchi A

更新日期：2010-11-01 00:00:00

abstract：:To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...

journal_title：Journal of bone and mineral metabolism

authors： Hojo H,Yano F,Ohba S,Igawa K,Nakajima K,Komiyama Y,Kan A,Ikeda T,Yonezawa T,Woo JT,Takato T,Nakamura K,Kawaguchi H,Chung UI

更新日期：2010-11-01 00:00:00

abstract：:Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and resorption activity have been shown to be enhanced in the presence of hypoxia. In the present study we examined the effects of the hypoxia mimetics dimethyloxallyl glyci...

journal_title：Journal of bone and mineral metabolism

authors： Leger AJ,Altobelli A,Mosquea LM,Belanger AJ,Song A,Cheng SH,Jiang C,Yew NS

更新日期：2010-09-01 00:00:00

abstract：:Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against o...

journal_title：Journal of bone and mineral metabolism

authors： Mehat MZ,Shuid AN,Mohamed N,Muhammad N,Soelaiman IN

更新日期：2010-09-01 00:00:00

abstract：:Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...

journal_title：Journal of bone and mineral metabolism

authors： Ryu J,Kim H,Chang EJ,Kim HJ,Lee Y,Kim HH

更新日期：2010-07-01 00:00:00

abstract：:A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to asse...

journal_title：Journal of bone and mineral metabolism

authors： Mori S,Fuku N,Chiba Y,Tokimura F,Hosoi T,Kimbara Y,Tamura Y,Araki A,Tanaka M,Ito H

更新日期：2010-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress has been reported to be linked to various diseases such as diabetes, neurodegenerative diseases, and osteogenesis imperfecta (OI). Old astrocyte specifically induced substance (OASIS), a novel type of ER stress transducer, is a basic leucine zipper transcription factor belonging to th...

journal_title：Journal of bone and mineral metabolism

authors： Sekiya H,Murakami T,Saito A,Hino S,Tsumagari K,Ochiai K,Imaizumi K

更新日期：2010-07-01 00:00:00

abstract：:High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B(12) stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B(12) in patients with Paget's disease of bone (PDB) and the effect of zoledr...

journal_title：Journal of bone and mineral metabolism

authors： Polyzos SA,Anastasilakis AD,Efstathiadou Z,Litsas I,Kita M,Panagiotou A,Papatheodorou A,Arsos G,Moralidis E,Barmpalios G,Zafeiriadou E,Triantafillidou E,Makrigiannaki E,Terpos E

更新日期：2010-05-01 00:00:00

abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...

journal_title：Journal of bone and mineral metabolism

authors： Tamaki J,Iki M,Sato Y,Kajita E,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2010-05-01 00:00:00

abstract：:Patients who are diagnosed with osteoporosis and beginning treatment often discontinue their osteoporosis medication relatively early after the start of treatment because of their poor recognition of fracture risk and the asymptomatic nature of osteoporosis. In this study we aimed to assess adherence to treatment with...

journal_title：Journal of bone and mineral metabolism

authors： Gorai I,Tanaka Y,Hattori S,Iwaoki Y

更新日期：2010-03-01 00:00:00

abstract：:Although the influence of weight-bearing activity on bone mass has been widely investigated in white women, few studies have been conducted in black, African populations. We investigated bone mineral density (BMD) in black South African women, with and without a history of load-carrying on the head. We also investigat...

journal_title：Journal of bone and mineral metabolism

authors： Lloyd R,Hind K,Micklesfield LK,Carroll S,Truscott JG,Parr B,Davies S,Cooke C

更新日期：2010-03-01 00:00:00

abstract：:Nitrogen-containing bisphosphonates such as zoledronic acid (ZOL) and pamidronate have been widely and successfully used for the treatment of cancer patients with bone metastases and/or hypercalcemia. Accumulating recent reports have shown that cancer patients who have received these bisphosphonates occasionally manif...

journal_title：Journal of bone and mineral metabolism

authors： Kobayashi Y,Hiraga T,Ueda A,Wang L,Matsumoto-Nakano M,Hata K,Yatani H,Yoneda T

更新日期：2010-03-01 00:00:00

abstract：:Concurrent use of bisphosphonate therapy reduces the anabolic effect of teriparatide. Consequently, in clinical practice bisphosphonates are discontinued and teriparatide therapy held for a few months to allow bone turnover to increase. We aimed to evaluate the effect of prior bisphosphonate exposure and the effect of...

journal_title：Journal of bone and mineral metabolism

authors： Keel C,Kraenzlin ME,Kraenzlin CA,Müller B,Meier C

更新日期：2010-01-01 00:00:00

abstract：:Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of th...

journal_title：Journal of bone and mineral metabolism

authors： Mikumo M,Okano H,Yoshikata R,Ishitani K,Ohta H

更新日期：2009-01-01 00:00:00

abstract：:In this study, we focused on collagen metabolism as a factor involved in menatetrenone (MK-4)-related improvement in bone quality. Using rats with a congenital ascorbic acid (AA) deficiency, osteogenic disorder Shionogi (ODS) rats, we established a model in which abnormal collagen metabolism reduced bone mechanical pr...

journal_title：Journal of bone and mineral metabolism

authors： Hara K,Akiyama Y

更新日期：2009-01-01 00:00:00

abstract：:Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 a...

journal_title：Journal of bone and mineral metabolism

authors： Ieni A,Barresi V,Grosso M,Rosa MA,Tuccari G

更新日期：2009-01-01 00:00:00

abstract：:We evaluated short-term changes in serum amino-terminal procollagen propeptide (P1NP) and cross-linked C-terminal telopeptide (betaCTX) of type I collagen after parathyroidectomy (PTX) in 41 postmenopausal women with primary hyperparathyroidism (PHPT). Serum levels of 25-hydroxyvitamin D, intact PTH, calcium, phosphat...

journal_title：Journal of bone and mineral metabolism

authors： Boudou P,Ibrahim F,Cormier C,Sarfati E,Souberbielle JC

更新日期：2009-01-01 00:00:00

abstract：:Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

journal_title：Journal of bone and mineral metabolism

authors： Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

更新日期：2009-01-01 00:00:00

abstract：:There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicul...

journal_title：Journal of bone and mineral metabolism

authors： Kashii M,Hashimoto J,Nakano T,Umakoshi Y,Yoshikawa H

更新日期：2008-01-01 00:00:00

abstract：:Advanced glycation end products (AGE) in collagen have been reported to decrease the mechanical property of bone. However, there are no available data on the relation between fracture risk and levels of glycoxidative (nonenzymatic) cross-links of collagen in clinical samples. A total of 432 Japanese elderly women who ...

journal_title：Journal of bone and mineral metabolism

authors： Shiraki M,Kuroda T,Tanaka S,Saito M,Fukunaga M,Nakamura T

更新日期：2008-01-01 00:00:00

abstract：:We designed a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism in the elderly living in a low-income housing unit in the city of Porto...

journal_title：Journal of bone and mineral metabolism

authors： Premaor MO,Scalco R,da Silva MJ,Froehlich PE,Furlanetto TW

更新日期：2008-01-01 00:00:00

abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

journal_title：Journal of bone and mineral metabolism

authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

更新日期：2008-01-01 00:00:00

abstract：:Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...

journal_title：Journal of bone and mineral metabolism

authors： Chappard C,Marchadier A,Benhamou L

更新日期：2008-01-01 00:00:00

abstract：:Simvastatin has been shown to stimulate osteogenesis both in vitro and in vivo. However, the mechanism by which simvastatin exerts its effects is still unclear. We previously reported that simvastatin promotes bone morphogenetic protein 2 (BMP-2) expression, induces osteoblastic differentiation, and inhibits adipocyti...

journal_title：Journal of bone and mineral metabolism

authors： Song C,Wang J,Song Q,Li X,Chen Z,Ma Q,Liu Z,Jia H,Dang G

更新日期：2008-01-01 00:00:00

abstract：:We have previously demonstrated the efficacy of therapeutic exercise for osteoarthritis (OA) of the knee. This study was performed to examine the additive effects of glucosamine or risedronate on the exercise therapy. In this study, 142 female patients with moderate OA of the knee, who had been recommended to undergo ...

journal_title：Journal of bone and mineral metabolism

authors： Kawasaki T,Kurosawa H,Ikeda H,Kim SG,Osawa A,Takazawa Y,Kubota M,Ishijima M

更新日期：2008-01-01 00:00:00

abstract：:Until now, the effects of phytoestrogen on bone in both women and ovarian hormone-deficient animal models of osteoporosis have remained uncertain. We have aimed here to investigate the effect of genistein (GEN) on trabecular bone quality in ovariectomized (OVX) rats. Forty 7-month-old female Sprague-Dawley rats were r...

journal_title：Journal of bone and mineral metabolism

authors： Dai R,Ma Y,Sheng Z,Jin Y,Zhang Y,Fang L,Fan H,Liao E

更新日期：2008-01-01 00:00:00

abstract：:We performed this study to clarify whether celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, prevents trabecular bone mass reduction by suppressing arthritis-related increase of bone resorption, and to discriminate differences in actions on bone among celecoxib, SC-58560 (a selective COX-1 inhibitor), and ind...

journal_title：Journal of bone and mineral metabolism

authors： Taketa T,Sakai A,Tanaka S,Nakai K,Menuki K,Yamane H,Tanaka K,Nakamura T

更新日期：2008-01-01 00:00:00

abstract：:Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...

journal_title：Journal of bone and mineral metabolism

authors： Sato T,Watanabe K,Masuhara M,Hada N,Hakeda Y

更新日期：2007-01-01 00:00:00

abstract：:Knee loading is a relatively new loading modality in which dynamic loads are laterally applied to the knee to induce bone formation in the tibia and the femur. The specific aim of the current study was to evaluate the effects of loading frequencies (in Hz) on bone formation at the site away from the loading site on th...

journal_title：Journal of bone and mineral metabolism

authors： Zhang P,Tanaka SM,Sun Q,Turner CH,Yokota H

更新日期：2007-01-01 00:00:00

abstract：:We evaluated adherence with raloxifene therapy compared with daily bisphosphonate in Asian postmenopausal women at increased risk of osteoporotic fractures. In this 12-month observational study conducted in Asia (Hong Kong, Malaysia, Pakistan, Philippines, Singapore, Taiwan), 984 postmenopausal women (aged 55 years or...

journal_title：Journal of bone and mineral metabolism

authors： Pasion EG,Sivananthan SK,Kung AW,Chen SH,Chen YJ,Mirasol R,Tay BK,Shah GA,Khan MA,Tam F,Hall BJ,Thiebaud D

更新日期：2007-01-01 00:00:00

abstract：:Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...

journal_title：Journal of bone and mineral metabolism

authors： Pi YZ,Wu XP,Liu SP,Luo XH,Cao XZ,Xie H,Liao EY

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have suggested that a high level of recent physical activity increases the risk of a wrist fracture in postmenopausal women. The relationship of more distant past physical activity to wrist fracture is less clear, and most studies have relied on recall of physical activity much earlier in life. The aim ...

journal_title：Journal of bone and mineral metabolism

authors： Thorpe DL,Knutsen SF,Beeson WL,Fraser GE

更新日期：2006-01-01 00:00:00

abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

journal_title：Journal of bone and mineral metabolism

authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

更新日期：2006-01-01 00:00:00

abstract：:Abeta-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Abeta-2M-amyloid fibril is beta2-microglobulin, and its elevated serum level is the main cause of Abeta-2M-amyloidosis in patients with kidney failure. However, the precis...

journal_title：Journal of bone and mineral metabolism

authors： Kazama JJ,Yamamoto S,Takahashi N,Ito Y,Maruyama H,Narita I,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：:Low levels of vitamin D nutrition (i.e., vitamin D insufficiency), which potentially cause osteoporosis, have been recognized as a common health problem for elderly people in European and North American countries, but there have been no studies on the prevalence of vitamin D insufficiency in Japan until recently. The ...

journal_title：Journal of bone and mineral metabolism

authors： Nakamura K

更新日期：2006-01-01 00:00:00

abstract：:Secondary hyperparathyroidism (SHPT) develops as a compensatory mechanism when the body is in calcium deficit. SHPT may be harmful and has been associated with elevated blood pressure. The cause of SHPT could be low calcium intake, reduced intestinal calcium absorption, or increased excretion. However, the relative im...

journal_title：Journal of bone and mineral metabolism

authors： Saleh F,Jorde R,Sundsfjord J,Haug E,Figenschau Y

更新日期：2006-01-01 00:00:00